Appamāda is heedfulness or vigilance, the opposite of negligence. The Dhammapada opens a chapter by calling it the path to the deathless and heedlessness the path to death, and the Buddha’s last words urged his followers to strive on with heedfulness. It is closely related to mindfulness.
Appamāda
Heedfulness: diligent, careful attention, which the Dhammapada calls the path to the deathless.
Also: Appamada, heedfulness